ABSTRACT A literature review on the clinical, laboratory, and treatment features of type B insulin resistance syndrome (TBIRS). Data from PubMed, the Virtual Health Library and Cochrane database were selected and analyzed using the REDCap application and R statistical program. From 182 papers, 65 were selected, which assessed 119 clinical cases, 76.5% in females and 42.9% in African-Americans, with an average age of 44 years. A common feature of TBIRS is co-occurrence of autoimmune diseases, such as systemic lupus erythematosus (most frequently reported). Hyperglycemia of difficult control was the mostly reported condition. Tests for anti-insulin receptor antibodies were positive in 44.2% of the cases. Disease management comprised fractional diet, insulin therapy (maximum dose given was 57 600 IU/day), plasmapheresis and immunosuppression with several classes of drugs, mainly glucocorticoids. Remission occurred in 69.7% of cases, in 30.3% of these spontaneously. The mortality rate was 15.38%. There was an inverse relationship between anti-insulin antibodies and remission (p = 0.033); and a positive correlation between combined immunosuppressive therapy and remission (p = 0.002). Relapse occurred in 7.6% of the cases. This rare syndrome has difficult-to-control diabetes, even with high doses of insulin, and it is usually associated with autoimmune diseases. Therapeutic advances using immunomodulatory therapy have led to significant improvements in the rate of remission.

Abstract Combined Sm-Nd isotope studies and U-Pb ages of detrital zircons have shown significant differences between the provenance patterns of Neoproterozoic metasedimentary successions in the Southern Brasília belt. The Vazante and Canastra groups are passive margin deposits with source areas in the Archean/Paleoproterozoic São Francisco Craton basement and Mesoproterozoic cover units. In literature, the younging trend of Nd model ages observed in the Vazante Group is interpreted as resulting from the contribution of the Neoproterozoic Goiás Magmatic Arc. Also, detrital zircons younger than 0.90 Ga were not recorded in the Vazante or Canastra groups, which zircon populations are older than 0.93 Ga. This work presents new Sm-Nd and Sr isotope data of metasedimentary rocks from the Vazante and Canastra groups, collected in a 400 km2 area in northwest Minas Gerais, Brazil. The improved database of previously published and new data corroborates with the younging pattern of TDM along the Vazante Group. Isochronic diagrams show that samples from Vazante and Canastra groups scatter along mixing lines between the fields defined by the older cratonic rocks and the more juvenile ones. Here we present the Tonian Intraplate Magmatism within the São Francisco Craton as the juvenile source.

RESUMO: O contato do empurrão dos grupos Canastra e Vazante na Faixa Brasília Meridional: evolução estrutural, cristalinidade de mica branca e implicações para a orogenia brasiliana. Duas escamas de cavalgamentos regionais de rochas metassedimentares neoproterozoicas ocorrem na Faixa Brasília Meridional, em Minas Gerais. A inferior compreende o Grupo Vazante, que na área de estudos é formado da base para o topo, pelas formações Serra do Garrote (metasiltitos e filitos carbonosos intercalados), Serra do Poço Verde (metadolomitos estromatolíticos bege a rosados com intercalações de ardósias e margas esverdeadas), Morro do Calcário (metadolomitos estromatolíticos cinza com intercalações de ardósias cinza) e Serra da Lapa (metarritmitos carbonosos com lentes de dolarenitos). A escama superior é composta do Grupo Canastra (formação Paracatu): sericita filitos laminados e filitos carbonosos com intercalações de quartzitos. A deformação resultou em quatro fases de deformação compressivas, contemporâneas ao metamorfismo de baixo grau. D 1 e D2 são de caráter dúctil, enquanto D3 e D4 são de regime rúptil-dúctil. D1 foi responsável pela clivagem ardosiana S1 subparalela ao acamamento sedimentar, com mergulhos baixos a altos para NW. D2 desenvolveu clivagem de crenulação (S2) que mergulha moderadamente para NW e está associada a dobras apertadas a isoclinais. D3 e D4 desenvolveram crenulações espaçadas e dobras abertas com kinks associadas. S3 apresenta eixos para NW, e S4, eixos para NE e SW, ambas com caimento moderados a altos. Medições por cristalinidade de mica branca (índice de Kübler) sugerem que os grupos Canastra e Vazante alcançaram condições de anquizona/epizona, e descontinuidades metamórficas ao longo dos planos de cavalgamento indicam que o pico metamórfico é anterior ou contemporâneo à tectônica de cavalgamento.

ABSTRACT: Two regional thrust-sheets of Neoproterozoic metasedimentary rocks occur in the Southern Brasília Belt, northwest Minas Gerais. The lower one comprises the Vazante Group, that is formed in the studied area, from base to top, by the Serra do Garrote (metapelites interlayered with carbonaceous phyllite), Serra do Poço Verde (beige to pink stromatolitic metadolomite with interlayered greenish slates), Morro do Calcário (gray stromatolitic metadolomite interlayered with gray slates) and Serra da Lapa (phyllite with dolarenitic lenses interlayered with slates) formations. The upper thrust sheet consists of the Canastra Group (Paracatu formation): laminated sericite phyllites and carbonaceous phyllites interlayered with quartzite. The Braziliano orogeny resulted in four phases of contractional deformation, associated with low-grade metamorphism. The first two (D1 and D2) are ductile, while the third and fourth ones (D3 and D4) are brittle-ductile. D1 developed a slaty S1 cleavage subparallel to the primary layering, with shallow to steep dips to NW. D2 developed a crenulation cleavage (S2) that dips moderately to NW and is associated with tight to isoclinal folds. D3 and D4 phases developed crenulations and open folds and kink bands. S3 dips steeply to NW, while S4 has moderate to steep dips to NE and SW. White mica crystallinity (Kübler index) measurements in metapelites indicate that both the Canastra and Vazante groups reached anchizone/epizone conditions, and metamorphic discontinuities along thrusts indicate that the peak of metamorphism is pre or syn-thrusting.

Objetivo: Caracterizar os conhecimentos dos utentes de duas Unidades de Saúde Familiar (USF) acerca da utilização de antibióticos. Tipo de estudo: Estudo observacional e transversal, com componente analítica. Local: USF das Conchas e Ars Médica. População: Utentes inscritos nas USF das Conchas e Ars Médica com 18 ou mais anos de idade (n=20.776). Métodos: Questionário anónimo aplicado a uma amostra de 380 utentes. Variáveis medidas: idade, sexo, escolaridade, nacionalidade, existência de filhos menores de 18 anos, conhecimentos sobre o uso de antibióticos e sua utilização sem prescrição médica. Resultados: A maioria era do sexo feminino (68,95%), tinha pelo menos o 12.º ano e nacionalidade portuguesa. Média de idades de 46 anos. Menos de metade tinha filhos menores de 18 anos (42,37%). A maioria (65,26%) respondeu que os antibióticos não servem para tratar tosse, dores no corpo, dor de garganta e «nariz a pingar» com a duração de cinco dias e 63,42% responderam que os antibióticos servem para tratar infeções causadas por bactérias. Menos de metade (48,98%) refere que os antibióticos não ajudam a recuperar mais rápido de uma gripe ou constipação. A maioria (67,89%) identificou a utilização de antibióticos como origem de infeções resistentes. No entanto, 17,11% dos utentes já tomou antibióticos sem prescrição médica. Verificou-se uma correlação fraca positiva entre a escolaridade e o número de respostas certas (r s=0,328). Os utentes que não se automedicaram responderam mais corretamente às questões (teste de Mann-Whitney p=0,002). Conclusão: Em geral, os utentes demonstraram conhecimentos superiores aos descritos na literatura portuguesa, possivelmente por se tratar de uma amostra com elevada escolaridade. A prevalência de automedicação esteve de acordo com os dados da literatura. Este estudo permitiu melhorar a perceção sobre os conhecimentos dos utentes em relação ao uso de antibióticos, bem como alertar para a automedicação como um problema de elevada prevalência.

Objectives: To assess patient knowledge about antibiotic use in two Family Health Units (FHU). Type of study: Cross-sectional study. Setting: FHU das Conchas and Ars Médica. Participants: Registered patients in the FHU das Conchas and Ars Médica 18 years of age or older. Methods: An anonymous questionnaire was administered to a sample of 380 patients. We collected data on age, gender, education, nationality, children under 18 years, knowledge about the use of antibiotics, and their use without prescription. Results: Most subjects were female (68.95%), had at least 12 years of education, and were Portuguese. The average age was 46 years. Less than half had children under the age of 18 (42.37%). The majority (65.26%) responded that antibiotics are not intended to treat cough, body aches, sore throat and ‘runny nose' with a duration of five days, and 63.42% responded that antibiotics are used to treat infections caused by bacteria. Less than half (48.98%) reported that antibiotics do not help to recover faster from a cold or flu. The majority (67.89%) identified the use of antibiotics as a cause of resistant infections. However, 17.11% had taken antibiotics without a prescription. There was a weak positive correlation between education and the number of correct responses (r s=0.328)). Patients who did not self-medicate had higher knowledge scores (Mann-Whitney p=0.002). Conclusion: These patients demonstrated greater knowledge of antibiotic use compared to previous findings in the Portuguese literature. This may be due to the high level of education in the sample. The prevalence of self-medication was similar to that previously reported in the literature. This study has improved our perception of our patients' knowledge of antibiotic use, and has drawn attention to the problem of self-medication.

Factors that Influence the Use of User Generated Content on the Internet. A Preliminary Study with Brazilian Travelers. The User Generated Content (UGC) is a significant factor in decision process of buying tourist products, and the hotel segment has been gaining attention in this area. The Theory of Planned Behavior (TPB) - and its three factors: attitude, subjective norms and perceived behavior control - was used to analyze the UGC as an influencing factor to choice a hotel, which explores the influence of intention behavioral in the decision making of travelers. It was developed a research instrument with closed questions, which was applied randomly in a big-sized hotel in Natal-RN. The methodology used was quantitative, and exploratory-descriptive. It was used surveys for data collection with Brazilian travelers, and the results of the analysis was conducted using Structural Equation Modeling (SEM) with the Partial Least Squares (PLS) technique. It was observed that most of the respondents use UGC, and they were influenced by UGC in the intention of choice of the hotel. The evaluation of the Structural Equation Modeling showed that two hypotheses were confirmed. The attitude factor of the traveler to use UGC had positive influence in their intention to use UGC when making travel plans. In addition, the subjective norms on the traveler to use UGC has positive influence in their intention to use UGC when making travel plans. This paper contributes to the current understanding of what factors influence the use of UGC when travelers make travel plans through a preliminary study with Brazilian travelers.

El Contenido Generado por el Usuario (CGU) ha resultado muy importante como factor decisorio en la compra de productos turísticos, destacándose el segmento hotelero. Para analizar el CGU como factor influyente al elegir un hotel se utilizó la Teoría del Comportamiento Planeado (TCP), basada en tres factores (actitud, normas subjetivas y control del comportamiento percibido). Se aplicó en un hotel de Natal un instrumento de investigación con preguntas cerradas de forma aleatoria. La metodología utilizada fue de tipo cuantitativa y descriptiva-exploratoria. Se realizó un relevamiento de datos de tipo Survey con viajeros brasileños y para analizar los resultados se usó el Modelo de Ecuaciones Estructurales (SEM) con la técnica Partial Least Squares (PLS). Se observó que la mayoría de los entrevistados utiliza el CGU, el cual influye en la elección del hotel. El factor actitud del viajero en usar CGU influye positivamente en su intención de utilizar CGU al planear un viaje. Las normas subjetivas al usar CGU influyen positivamente en la intención del viajero de utilizar CGU al planear un viaje. Este artículo contribuye a entender qué factores influyen en el uso de CGU cuando los viajeros hacen planes de viajes a través de un estudio preliminar con viajeros brasileños.